KIAA2012

Across TCGA patient cohorts, KIAA2012 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIAA2012-associated genes across cancer lineages are Smad3, ATM, and 14-3-3_beta. Each is linked with KIAA2012 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIAA2012-to-partner and partner-to-KIAA2012 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad3 grouped by KIAA2012-low versus KIAA2012-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA2012→partner) and Y-score (partner→KIAA2012) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Smad3 →	+0.116	+3.169	.040	.018	3	2
UCEC	ATM →	-0.561	-3.700	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.093	-3.432	.013	.005	3	1
UCEC	eEF2 →	+0.380	+3.169	.004	.018	3	1
UCEC	EGFR_pY1068 →	-0.287	-3.459	.002	.005	3	1
UCEC	eIF4E →	+0.174	+2.807	.028	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Smad3 by KIAA2012 expression — UCEC

Explore this box plot interactively →