KIAA2012

Across TCGA pan-cancer cohorts, KIAA2012 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated KIAA2012 data layer compared with 3 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher KIAA2012 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KIAA2012 expression acts as an unfavorable survival marker, although some lineages such as LIHC and DLBC show a favorable association.

ACC, KIRC, and LIHC are the cancer types where KIAA2012 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.354	0.747	<.001	112	view →
KIRC	DFS	Quartile	II,III,IV	0.381	0.603	.002	104	view →
LIHC	OS	Median	III,IV	0.513	0.221	.004	32	view →
KIRP	OS	Tertile	III,IV	0.184	0.688	.008	30	view →
LGG	OS	Quartile	All	0.454	0.616	<.001	26	view →
DLBC	OS	Quartile	II,III,IV	1.000	0.461	.028	22	view →
LUAD	DFS	Median	IV	0.240	0.843	.001	18	view →
MESO	OS	Quartile	All	0.787	0.283	.026	16	view →
READ	DFS	Quartile	IV	0.397	0.795	.003	15	view →
TGCT	DFS	Tertile	All	0.475	0.813	.008	14	view →
SARC	OS	Tertile	All	0.918	0.783	.006	13	view →
STAD	DFS	Tertile	IV	0.741	0.143	.025	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

KIAA2012–ACC (OS)

Open the ACC breakdown →