KIAA1549L

Across TCGA patient cohorts, KIAA1549L mutation is significantly associated with the RNA expression of many other genes, with 6,709 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIAA1549L-associated genes across cancer lineages are MTHFD2, RPL7P31, and GOT1. Each is linked with KIAA1549L in more than 4 cancer types. Because this analysis shows association rather than direction, both KIAA1549L-to-partner and partner-to-KIAA1549L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTHFD2 grouped by KIAA1549L-low versus KIAA1549L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA1549L→partner) and Y-score (partner→KIAA1549L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTHFD2 →	+0.481	+1.600	<.001	<.001	3	5
READ	RPL7P31 →	+0.118	+3.456	<.001	.002	3	4
COAD	GOT1 →	+0.389	+2.820	.001	.001	3	4
UCEC	WRAP53 →	+0.332	+1.360	<.001	<.001	3	4
COAD	SRP19 →	+0.365	+2.288	.008	.001	3	4
LUAD	EXO1 →	+0.646	+1.909	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,709 associations by consensus.

MTHFD2 by KIAA1549L expression — UCEC

Explore this box plot interactively →