KIAA1549L

Across TCGA pan-cancer cohorts, KIAA1549L RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of KIAA1549L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KIAA1549L RNA is repressed in tumor relative to normal tissue. In most cancer types KIAA1549L is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, HNSC, and LUSC are the cancer types where KIAA1549L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIAA1549L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.131	<.001	12	view →
HNSC	Female	III,IV	+1.331	<.001	11	view →
LUSC	All	II,III,IV	+2.022	<.001	8	view →
COAD	All	II,III,IV	+0.653	<.001	8	view →
KIRP	Male	All	−0.750	<.001	7	view →
LUAD	Female	II,III,IV	+0.710	<.001	7	view →
UCEC	All	All	+0.836	.003	6	view →
BRCA	All	II,III,IV	+0.670	<.001	6	view →
THCA	All	All	+0.284	<.001	5	view →
STAD	Male	All	+0.570	.022	4	view →
CHOL	All	All	+1.496	<.001	3	view →
BLCA	Male	III,IV	+1.855	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

KIAA1549L–KIRC

Open the KIRC breakdown →