KIAA1549

Across TCGA patient cohorts, KIAA1549 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIAA1549-associated genes across cancer lineages are FoxM1, Cyclin-E2, and Ku80. Each is linked with KIAA1549 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIAA1549-to-partner and partner-to-KIAA1549 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by KIAA1549-low versus KIAA1549-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA1549→partner) and Y-score (partner→KIAA1549) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	FoxM1 →	+0.345	+2.459	<.001	.018	3	3
UCEC	Cyclin-E2 →	+0.185	+2.321	<.001	<.001	3	3
UCEC	Ku80 →	+0.250	+2.112	<.001	<.001	3	3
SKCM	c-Kit →	-0.565	-1.736	.003	.005	3	3
UCEC	Cyclin-B1 →	+0.579	+3.906	<.001	<.001	3	3
LUSC	MEK1_p_S217_S221 →	-0.136	-2.431	.012	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

FoxM1 by KIAA1549 expression — LUSC

Explore this box plot interactively →