KIAA1549

Across TCGA pan-cancer cohorts, KIAA1549 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated KIAA1549 data layer compared with 6 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher KIAA1549 RNA is associated with better overall survival. In most high-consensus cancer types, elevated KIAA1549 expression acts as an unfavorable survival marker, although some lineages such as KIRC and OV show a favorable association.

KIRC, MESO, and OV are the cancer types where KIAA1549 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.740	0.533	<.001	150	view →
MESO	OS	Tertile	All	0.303	0.531	.001	99	view →
OV	DFS	Median	All	0.588	0.491	.005	46	view →
LAML	DFS	Quartile	All	0.759	0.282	<.001	34	view →
CESC	DFS	Quartile	All	0.633	0.867	<.001	30	view →
PAAD	OS	Median	II,III,IV	0.502	0.735	.009	29	view →
UCS	OS	Tertile	II,III,IV	0.603	0.268	.026	24	view →
LGG	OS	Tertile	All	0.935	0.811	.002	23	view →
LUAD	DFS	Median	All	0.741	0.839	.001	21	view →
SCLC	OS	Quartile	II,III,IV	0.811	0.427	.005	18	view →
COAD	DFS	Tertile	III,IV	0.742	0.462	.003	17	view →
KICH	OS	Quartile	III,IV	0.387	1.000	.007	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

KIAA1549–KIRC (OS)

Open the KIRC breakdown →