KIAA1549

Across TCGA pan-cancer cohorts, KIAA1549 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of KIAA1549’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where KIAA1549 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KIAA1549 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, LIHC, and BLCA are the cancer types where KIAA1549 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIAA1549 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+2.258	<.001	12	view →
LIHC	Male	II,III,IV	+1.097	<.001	8	view →
BLCA	All	All	+1.036	<.001	8	view →
HNSC	All	II,III,IV	+0.572	.013	8	view →
STAD	Male	II,III,IV	+1.298	<.001	6	view →
UCEC	All	III,IV	+1.136	.007	6	view →
KICH	All	All	−0.704	<.001	6	view →
READ	All	All	+1.450	<.001	5	view →
THCA	All	All	+0.340	.001	5	view →
BRCA	All	II,III,IV	+0.405	<.001	4	view →
CHOL	Female	All	+2.060	<.001	3	view →
LUSC	All	All	+0.652	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

KIAA1549–COAD

Open the COAD breakdown →