KIAA1522

Across TCGA cell cohorts, KIAA1522 mutation is significantly associated with the RNA expression of many other genes, with 576 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIAA1522-associated genes across cancer lineages are PFN3, C1orf189, and LRRC38. Each is linked with KIAA1522 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIAA1522-to-partner and partner-to-KIAA1522 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFN3 grouped by KIAA1522-low versus KIAA1522-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA1522→partner) and Y-score (partner→KIAA1522) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PFN3 →	+0.057	+4.450	<.001	.004	3	2
LARGE_INTESTINE	C1orf189 →	+0.094	+2.054	<.001	.008	3	2
BLOOD_Leukemia	LRRC38 →	+1.476	+3.631	<.001	.006	3	1
BLOOD_Leukemia	C4orf50 →	+0.149	+3.974	.006	.002	3	1
BLOOD_Leukemia	ELOA3DP →	+0.092	+3.007	.007	.007	3	1
BLOOD_Leukemia	KHDC3L →	+0.139	+3.607	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 576 associations by consensus.

PFN3 by KIAA1522 expression — OVARY

Explore this box plot interactively →