KIAA1522

Across TCGA pan-cancer cohorts, KIAA1522 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated KIAA1522 data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher KIAA1522 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KIAA1522 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CHOL show a favorable association.

LIHC, LGG, and ACC are the cancer types where KIAA1522 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.454	0.626	<.001	77	view →
LGG	OS	Median	All	0.718	0.899	<.001	54	view →
ACC	DFS	Median	All	0.242	0.690	<.001	45	view →
SKCM	OS	Median	III,IV	0.616	0.786	.001	30	view →
HNSC	DFS	Quartile	All	0.798	0.627	.001	30	view →
PAAD	OS	Quartile	All	0.562	0.796	.003	27	view →
CHOL	OS	Tertile	All	0.939	0.550	.014	21	view →
KIRP	DFS	Median	III,IV	0.732	0.243	.028	8	view →
BRCA	OS	Tertile	All	0.947	0.899	.012	8	view →
OV	OS	Quartile	III,IV	0.263	0.347	.027	6	view →
DLBC	OS	Quartile	IV	0.931	0.287	.038	6	view →
TGCT	DFS	Tertile	All	0.598	0.857	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

KIAA1522–LIHC (DFS)

Open the LIHC breakdown →