KIAA1109

Across TCGA patient cohorts, KIAA1109 mutation is significantly associated with the total protein of many other genes, with 86 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIAA1109-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and Cyclin-B1. Each is linked with KIAA1109 in more than 4 cancer types. Because this analysis shows association rather than direction, both KIAA1109-to-partner and partner-to-KIAA1109 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KIAA1109-low versus KIAA1109-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA1109→partner) and Y-score (partner→KIAA1109) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+0.876	+3.584	.001	.002	3	5
UCEC	PCNA →	+0.140	+1.222	.006	.001	3	5
UCEC	Cyclin-B1 →	+0.425	+1.109	.001	.003	3	5
LUSC	GAPDH →	+0.788	+3.247	<.001	<.001	3	3
LUAD	MYH11 →	-1.071	-2.222	<.001	.009	3	3
LUSC	Bim →	+0.208	+1.485	.011	.048	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

Caspase-7-cleavedD198 by KIAA1109 expression — STAD

Explore this box plot interactively →