KIAA1109

Across TCGA pan-cancer cohorts, KIAA1109 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of KIAA1109’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where KIAA1109 RNA is repressed in tumor relative to normal tissue. In most cancer types KIAA1109 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and BRCA are the cancer types where KIAA1109 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIAA1109 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−1.087	<.001	8	view →
COAD	Female	All	−0.944	<.001	7	view →
BRCA	All	III,IV	−0.790	<.001	6	view →
KIRC	All	II,III,IV	−0.368	.009	6	view →
KIRP	Male	All	−0.837	<.001	5	view →
LUSC	All	All	−0.646	<.001	5	view →
UCEC	All	All	−0.967	<.001	4	view →
CHOL	All	All	+1.046	.001	2	view →
LUAD	Female	II,III,IV	−0.681	.028	2	view →
LIHC	All	All	+0.330	.010	2	view →
READ	All	All	−0.648	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

KIAA1109–THCA

Open the THCA breakdown →