KIAA1109

Across TCGA pan-cancer cohorts, KIAA1109 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated KIAA1109 data layer compared with 11 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher KIAA1109 RNA is associated with better overall survival. In most high-consensus cancer types, elevated KIAA1109 expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

KIRC, READ, and BRCA are the cancer types where KIAA1109 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.730	0.543	<.001	111	view →
READ	OS	Median	II,III,IV	0.830	0.318	<.001	43	view →
BRCA	DFS	Quartile	III,IV	0.941	0.749	<.001	36	view →
SKCM	DFS	Median	All	0.238	0.166	.003	35	view →
HNSC	DFS	Median	All	0.405	0.281	.004	28	view →
LUAD	OS	Median	All	0.852	0.773	.002	26	view →
LUSC	DFS	Median	III,IV	0.407	0.883	.006	25	view →
ACC	OS	Median	III,IV	0.855	0.630	.024	23	view →
UVM	DFS	Quartile	III,IV	0.182	0.713	.010	21	view →
OV	OS	Median	III,IV	0.791	0.875	.020	14	view →
UCS	DFS	Tertile	IV	0.956	0.381	.024	14	view →
CESC	DFS	Tertile	All	0.500	0.760	.023	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

KIAA1109–KIRC (OS)

Open the KIRC breakdown →