KIAA1109

Across TCGA cell cohorts, KIAA1109 mutation is significantly associated with the RNA expression of many other genes, with 1,788 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIAA1109-associated genes across cancer lineages are TTC19, SLC66A1, and TRABD. Each is linked with KIAA1109 in more than 3 cancer types. Because this analysis shows association rather than direction, both KIAA1109-to-partner and partner-to-KIAA1109 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTC19 grouped by KIAA1109-low versus KIAA1109-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA1109→partner) and Y-score (partner→KIAA1109) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTC19 →	+0.709	+2.807	<.001	<.001	3	4
LUNG_SCLC	SLC66A1 →	+0.774	+3.169	<.001	.006	3	4
LARGE_INTESTINE	TRABD →	+0.692	+2.115	<.001	.004	3	4
PANCREAS	IRX1 →	+0.015	+3.184	<.001	.003	3	3
STOMACH	GOSR2 →	-0.534	-2.862	.005	.007	3	3
STOMACH	DUSP3 →	-0.789	-2.251	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,788 associations by consensus.

TTC19 by KIAA1109 expression — LARGE_INTESTINE

Explore this box plot interactively →