KIAA0586

Across TCGA patient cohorts, KIAA0586 mutation is significantly associated with the RNA expression of many other genes, with 5,336 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIAA0586-associated genes across cancer lineages are NUP188, CDCA2, and MAPKAP1. Each is linked with KIAA0586 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIAA0586-to-partner and partner-to-KIAA0586 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUP188 grouped by KIAA0586-low versus KIAA0586-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA0586→partner) and Y-score (partner→KIAA0586) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUP188 →	+0.608	+2.700	<.001	<.001	3	3
UCEC	CDCA2 →	+0.918	+2.440	<.001	<.001	3	3
LUAD	MAPKAP1 →	+0.550	+3.222	<.001	.009	3	3
COAD	GMEB1 →	+0.391	+3.920	<.001	<.001	3	3
COAD	CHCHD4 →	+0.401	+3.947	<.001	<.001	3	3
UCEC	CNTROB →	+0.372	+1.818	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,336 associations by consensus.

NUP188 by KIAA0586 expression — UCEC

Explore this box plot interactively →