KIAA0319L

Across TCGA pan-cancer cohorts, KIAA0319L mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KIAA0319L data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher KIAA0319L mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KIAA0319L expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where KIAA0319L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.366	0.800	.002	48	view →
PDAC	OS	Tertile	IV	0.472	0.973	.024	6	view →
HNSC	DFS	Median	All	0.845	0.717	.013	6	view →
LUAD	DFS	Tertile	All	0.799	0.962	.037	2	view →
UCEC	OS	Median	All	0.982	0.918	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KIAA0319L–CCRCC (DFS)

Open the CCRCC breakdown →