KHDRBS3

Across TCGA patient cohorts, KHDRBS3 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KHDRBS3-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and ERK2. Each is linked with KHDRBS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KHDRBS3-to-partner and partner-to-KHDRBS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by KHDRBS3-low versus KHDRBS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KHDRBS3→partner) and Y-score (partner→KHDRBS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.272	-3.584	.004	.002	3	1
UCEC	eIF4E →	+0.234	+3.247	.003	<.001	3	1
UCEC	ERK2 →	+0.207	+2.584	.005	.010	3	1
UCEC	INPP4B →	-0.316	-2.807	.010	.002	3	1
UCEC	p62 Lck ligand →	+0.383	+3.584	.002	.002	3	1
UCEC	PCNA →	+0.247	+2.115	.002	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by KHDRBS3 expression — UCEC

Explore this box plot interactively →