KHDRBS3

Across TCGA pan-cancer cohorts, KHDRBS3 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated KHDRBS3 data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher KHDRBS3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KHDRBS3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

UVM, KIRC, and SKCM are the cancer types where KHDRBS3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.397	0.800	<.001	130	view →
KIRC	OS	Median	All	0.740	0.533	<.001	68	view →
SKCM	OS	Tertile	All	0.412	0.247	<.001	59	view →
ACC	DFS	Median	II,III,IV	0.147	0.785	<.001	40	view →
LIHC	OS	Quartile	All	0.580	0.771	.001	40	view →
LGG	DFS	Median	All	0.788	0.680	.002	36	view →
KICH	DFS	Quartile	All	0.618	1.000	.003	33	view →
SCLC	OS	Quartile	II,III,IV	0.688	0.296	.002	28	view →
BLCA	OS	Median	IV	0.148	0.439	.008	23	view →
LUAD	DFS	Tertile	IV	0.309	0.807	.014	12	view →
COAD	OS	Quartile	All	0.885	0.652	.005	9	view →
HNSC	DFS	Tertile	IV	0.733	0.494	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

KHDRBS3–UVM (DFS)

Open the UVM breakdown →