KDM8

Across TCGA patient cohorts, KDM8 mutation is significantly associated with the RNA expression of many other genes, with 3,935 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM8-associated genes across cancer lineages are RN7SL371P, GAGE2E, and RN7SL302P. Each is linked with KDM8 in more than 2 cancer types. Because this analysis shows association rather than direction, both KDM8-to-partner and partner-to-KDM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL371P grouped by KDM8-low versus KDM8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM8→partner) and Y-score (partner→KDM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SL371P →	+0.160	+5.792	<.001	.003	3	3
SKCM	GAGE2E →	+0.731	+2.947	<.001	.002	3	2
SKCM	RN7SL302P →	+0.056	+3.069	.001	.009	3	2
COAD	TRGJP2 →	+0.968	+3.489	<.001	.005	3	2
UCEC	TRAJ57 →	+0.304	+1.926	.001	.002	3	2
UCEC	NOP14-AS1 →	+0.291	+1.975	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,935 associations by consensus.

RN7SL371P by KDM8 expression — LUSC

Explore this box plot interactively →