KDM8

Across TCGA pan-cancer cohorts, KDM8 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of KDM8’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where KDM8 RNA is repressed in tumor relative to normal tissue. In most cancer types KDM8 is over-expressed in tumor, although a few such as LIHC and THCA show the opposite, repressed pattern.

LIHC, THCA, and KIRC are the cancer types where KDM8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KDM8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	II,III,IV	−2.510	<.001	9	view →
THCA	Male	IV	−0.656	<.001	9	view →
KIRC	Female	All	+0.353	<.001	9	view →
LUSC	Male	III,IV	−0.752	.006	6	view →
CHOL	All	All	−2.633	<.001	5	view →
KICH	Male	III,IV	−0.790	.026	4	view →
UCEC	All	All	−0.616	<.001	4	view →
STAD	Female	All	+0.510	.031	2	view →
HNSC	All	All	+0.206	.020	2	view →
COAD	Female	III,IV	−0.427	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

KDM8–LIHC

Open the LIHC breakdown →