KDM7A-DT

Across TCGA pan-cancer cohorts, KDM7A-DT RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated KDM7A-DT data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher KDM7A-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KDM7A-DT expression acts as an unfavorable survival marker, although some lineages such as SKCM and MESO show a favorable association.

UVM, SKCM, and BLCA are the cancer types where KDM7A-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.393	0.833	<.001	137	view →
SKCM	DFS	Median	All	0.276	0.144	<.001	69	view →
BLCA	DFS	Quartile	All	0.215	0.419	.006	39	view →
KICH	OS	Median	All	0.814	1.000	.005	34	view →
GBM	OS	Quartile	All	0.301	0.494	.002	15	view →
COAD	DFS	Tertile	All	0.271	0.581	.010	15	view →
MESO	OS	Median	IV	0.795	0.364	.021	14	view →
CHOL	DFS	Median	III,IV	0.647	0.127	.006	13	view →
BRCA	DFS	Median	III,IV	0.840	0.916	.007	13	view →
LAML	DFS	Tertile	All	0.751	0.406	.003	12	view →
ACC	OS	Tertile	III,IV	0.340	0.877	.011	10	view →
LUAD	OS	Median	III,IV	0.765	0.514	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

KDM7A-DT–UVM (DFS)

Open the UVM breakdown →