KDM7A-DT

Across TCGA pan-cancer cohorts, KDM7A-DT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KDM7A-DT’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where KDM7A-DT RNA is repressed in tumor relative to normal tissue. In most cancer types KDM7A-DT is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, UCEC, and KIRC are the cancer types where KDM7A-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KDM7A-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.757	<.001	10	view →
UCEC	All	All	+1.218	<.001	6	view →
KIRC	Male	II,III,IV	−0.768	<.001	6	view →
LIHC	Female	All	+0.562	<.001	6	view →
LUSC	Female	All	+1.146	<.001	4	view →
PAAD	All	All	+0.962	.004	4	view →
LUAD	Female	II,III,IV	+0.770	<.001	4	view →
KICH	All	All	−0.853	.001	3	view →
HNSC	All	All	+0.396	.021	3	view →
ESCA	Male	All	+0.756	.037	2	view →
PRAD	All	All	+0.488	<.001	2	view →
STAD	All	All	+0.423	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KDM7A-DT–THCA

Open the THCA breakdown →