KDM5C-IT1

Across TCGA patient cohorts, KDM5C-IT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,709 significant associations in total. STAD shows the largest number of these associations.

The most reproducible KDM5C-IT1-associated GO terms across cancer lineages are TOR signaling, TORC1 signaling, and Regulation of RNA splicing. Each is linked with KDM5C-IT1 in more than 27 cancer types. Because this analysis shows association rather than direction, both KDM5C-IT1-to-partner and partner-to-KDM5C-IT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOR signaling grouped by KDM5C-IT1-low versus KDM5C-IT1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM5C-IT1→partner) and Y-score (partner→KDM5C-IT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TOR signaling →	+0.043	+0.134	<.001	<.001	3	28
STAD	TORC1 signaling →	+0.051	+0.142	<.001	<.001	3	28
ESCA	Regulation of RNA splicing →	+0.061	+0.223	<.001	<.001	3	28
ESCA	Response to ionizing radiation →	+0.046	+0.176	<.001	<.001	3	27
ESCA	RNA methylation →	+0.039	+0.204	<.001	<.001	3	27
STAD	Peptidyl-lysine modification →	+0.040	+0.130	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,709 associations by consensus.

TOR signaling by KDM5C-IT1 expression — STAD

Explore this box plot interactively →