KDM5C-IT1

Across TCGA pan-cancer cohorts, KDM5C-IT1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated KDM5C-IT1 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher KDM5C-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KDM5C-IT1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LAML show a favorable association.

THCA, LUAD, and UVM are the cancer types where KDM5C-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	III,IV	0.721	0.914	<.001	61	view →
LUAD	OS	Tertile	II,III,IV	0.822	0.670	.003	41	view →
UVM	DFS	Tertile	All	0.355	0.786	.002	33	view →
KIRP	DFS	Quartile	All	0.437	0.650	.002	32	view →
COAD	OS	Median	II,III,IV	0.791	0.888	.013	24	view →
LAML	DFS	Median	All	0.473	0.270	.005	22	view →
OV	DFS	Quartile	II,III,IV	0.256	0.144	.017	16	view →
ACC	DFS	Median	All	0.765	0.344	.015	16	view →
BLCA	OS	Tertile	III,IV	0.521	0.298	.010	15	view →
READ	OS	Median	II,III,IV	0.827	0.392	.003	14	view →
HNSC	DFS	Quartile	All	0.198	0.420	.006	12	view →
KIRC	DFS	Quartile	All	0.658	0.826	.021	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

KDM5C-IT1–THCA (DFS)

Open the THCA breakdown →