KDM5C-IT1

Across TCGA pan-cancer cohorts, KDM5C-IT1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of KDM5C-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where KDM5C-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KDM5C-IT1 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

STAD, LUSC, and LUAD are the cancer types where KDM5C-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KDM5C-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	Male	All	+0.126	.009	4	view →
LUSC	Female	III,IV	−0.130	.005	1	view →
LUAD	All	III,IV	−0.105	.020	1	view →
KICH	Female	All	−0.096	.037	1	view →
THCA	All	All	−0.041	.037	1	view →
HNSC	Male	II,III,IV	+0.025	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

KDM5C-IT1–STAD

Open the STAD breakdown →