KDM4C

Across TCGA cell cohorts, KDM4C mutation is significantly associated with the RNA expression of many other genes, with 264 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KDM4C-associated genes across cancer lineages are OR52N5, ARGFX, and FAM47C. Each is linked with KDM4C in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM4C-to-partner and partner-to-KDM4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52N5 grouped by KDM4C-low versus KDM4C-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM4C→partner) and Y-score (partner→KDM4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	OR52N5 →	+0.026	+5.357	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	ARGFX →	+0.083	+5.357	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	FAM47C →	+0.069	+4.736	<.001	.009	3	2
BLOOD_Lymphoma	ZNF804B →	+0.013	+4.350	<.001	.005	3	2
BLOOD_Lymphoma	OR4N4 →	+0.071	+4.191	<.001	.007	3	2
CNS	MTRNR2L6 →	+0.015	+5.357	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 264 associations by consensus.

OR52N5 by KDM4C expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →