KDM4B

Across TCGA patient cohorts, KDM4B mutation is significantly associated with the RNA expression of many other genes, with 5,650 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM4B-associated genes across cancer lineages are KMT5AP1, VDAC1P7, and RNU6-218P. Each is linked with KDM4B in more than 3 cancer types. Because this analysis shows association rather than direction, both KDM4B-to-partner and partner-to-KDM4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KMT5AP1 grouped by KDM4B-low versus KDM4B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM4B→partner) and Y-score (partner→KDM4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	KMT5AP1 →	+0.247	+2.223	<.001	.001	3	4
HNSC	VDAC1P7 →	+0.112	+3.909	<.001	.002	3	3
SKCM	RNU6-218P →	+0.343	+2.092	<.001	.001	3	3
LUSC	RNU6-267P →	+0.264	+2.750	<.001	.008	3	3
COAD	PTMAP9 →	+0.654	+2.196	<.001	.001	3	3
UCEC	HSP90AA3P →	+0.187	+1.896	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,650 associations by consensus.

KMT5AP1 by KDM4B expression — COAD

Explore this box plot interactively →