KDM4B

Across TCGA pan-cancer cohorts, KDM4B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated KDM4B data layer compared with 8 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher KDM4B RNA is associated with better overall survival. In most high-consensus cancer types, elevated KDM4B expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCEC show a favorable association.

BRCA, UCEC, and ACC are the cancer types where KDM4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.958	0.888	<.001	113	view →
UCEC	OS	Median	All	0.859	0.552	<.001	106	view →
ACC	DFS	Median	All	0.206	0.704	<.001	101	view →
MESO	OS	Tertile	III,IV	0.418	0.662	.010	78	view →
UVM	OS	Quartile	All	0.908	0.634	.011	31	view →
HNSC	DFS	Tertile	IV	0.409	0.227	.005	31	view →
KIRC	DFS	Tertile	IV	0.653	0.287	.008	26	view →
LGG	OS	Median	All	0.945	0.827	<.001	23	view →
SKCM	DFS	Tertile	III,IV	0.546	0.798	.004	22	view →
LUAD	DFS	Tertile	IV	0.384	0.906	.004	20	view →
GBM	OS	Median	All	0.553	0.264	<.001	18	view →
COAD	OS	Quartile	All	0.662	0.850	.014	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

KDM4B–BRCA (OS)

Open the BRCA breakdown →