Q-omics provides the consensus-scored HSP90AA3P profile across patient tissues and cancer cell-line models. HSP90AA3P expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, HSP90AA3P is differentially expressed in 10, with the highest sampling consensus in KIRC. Additionally, HSP90AA3P RNA expression shows 16,084 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and KIRC as cancer lineages where HSP90AA3P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HSP90AA3P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HSP90AA3P survival associations across molecular data types. HSP90AA3P RNA expression shows survival associations in the most cancer types (26). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HSP90AA3P RNA expression–survival associations across cancer types. High HSP90AA3P expression shows unfavorable associations in UVM, LUAD, BRCA, HNSC and MESO, but favorable associations in LUSC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for HSP90AA3P RNA expression.
This table summarizes HSP90AA3P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for HSP90AA3P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HSP90AA3P shows lower tumor expression in KIRC and higher tumor expression in COAD, HNSC, LIHC, BRCA and LUSC. The KIRC box plot shows higher HSP90AA3P RNA expression in normal versus tumor tissue (log2 FC = −0.159, t-test p < 0.001).
This table shows molecular features associated with HSP90AA3P in patient tissues and cancer cell lines. In patient samples, HSP90AA3P shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
