HSP90AA3P

Across TCGA pan-cancer cohorts, HSP90AA3P RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HSP90AA3P data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher HSP90AA3P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSP90AA3P expression acts as an unfavorable survival marker, although some lineages such as LUSC and OV show a favorable association.

UVM, LUAD, and BRCA are the cancer types where HSP90AA3P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	III,IV	0.380	0.930	<.001	50	view →
LUAD	DFS	Median	III,IV	0.479	0.749	.004	40	view →
BRCA	DFS	Tertile	All	0.508	0.583	.008	33	view →
LUSC	DFS	Median	II,III,IV	0.793	0.622	.005	22	view →
HNSC	OS	Median	All	0.712	0.787	.006	21	view →
MESO	OS	Median	III,IV	0.282	0.474	.012	20	view →
OV	DFS	Tertile	IV	0.561	0.320	.007	18	view →
DLBC	DFS	Quartile	All	0.292	0.784	.016	14	view →
LGG	OS	Quartile	All	0.724	0.898	.007	11	view →
BLCA	DFS	Tertile	II,III,IV	0.280	0.410	.018	9	view →
ESCA	DFS	Tertile	IV	0.372	0.785	.024	9	view →
ACC	DFS	Median	All	0.583	0.863	.012	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HSP90AA3P–UVM (DFS)

Open the UVM breakdown →