KDM3A

Across TCGA patient cohorts, KDM3A mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM3A-associated genes across cancer lineages are 4E-BP1, A-Raf_pS299, and Rictor_pT1135. Each is linked with KDM3A in more than 3 cancer types. Because this analysis shows association rather than direction, both KDM3A-to-partner and partner-to-KDM3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by KDM3A-low versus KDM3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM3A→partner) and Y-score (partner→KDM3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.355	+3.700	<.001	.001	3	4
UCEC	A-Raf_pS299 →	-0.102	-3.584	.015	.002	3	3
UCEC	Rictor_pT1135 →	-0.081	-2.321	.025	.033	3	3
UCEC	TFRC →	+0.655	+4.000	<.001	<.001	3	3
COAD	Notch1 →	+0.230	+2.815	.023	.036	2	3
UCEC	eIF4E →	+0.197	+3.472	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

4E-BP1 by KDM3A expression — UCEC

Explore this box plot interactively →