KDM3A

Across TCGA pan-cancer cohorts, KDM3A RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated KDM3A data layer compared with 10 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher KDM3A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KDM3A expression acts as an unfavorable survival marker, although some lineages such as KIRC and LAML show a favorable association.

MESO, KIRC, and ACC are the cancer types where KDM3A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	All	0.265	0.542	<.001	88	view →
KIRC	DFS	Tertile	All	0.792	0.511	<.001	73	view →
ACC	DFS	Median	All	0.269	0.649	<.001	73	view →
LIHC	OS	Median	All	0.710	0.839	<.001	55	view →
KIRP	DFS	Quartile	II,III,IV	0.525	0.860	.002	51	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
LUSC	DFS	Tertile	III,IV	0.521	0.802	.003	24	view →
PCPG	OS	Median	All	0.731	1.000	.017	20	view →
KICH	OS	Quartile	All	0.624	1.000	.012	20	view →
CESC	DFS	Quartile	All	0.421	0.718	.021	18	view →
LAML	DFS	Median	All	0.719	0.429	.004	16	view →
OV	OS	Tertile	III,IV	0.249	0.386	.007	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

KDM3A–MESO (DFS)

Open the MESO breakdown →