KDM3A

Across TCGA pan-cancer cohorts, KDM3A RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of KDM3A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KDM3A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KDM3A is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where KDM3A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KDM3A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.259	<.001	12	view →
KIRP	Female	All	+1.096	<.001	11	view →
HNSC	Male	All	+0.821	<.001	10	view →
LIHC	All	II,III,IV	+0.881	<.001	9	view →
COAD	Male	IV	+1.339	<.001	8	view →
BLCA	All	All	+0.603	.004	7	view →
CHOL	Male	All	+1.946	<.001	5	view →
LUSC	Male	II,III,IV	+0.963	<.001	5	view →
UCEC	All	II,III,IV	+0.536	.039	4	view →
THCA	All	All	−0.315	.003	4	view →
LUAD	All	All	+0.307	.002	3	view →
PAAD	Male	All	+0.635	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

KDM3A–KIRC

Open the KIRC breakdown →