KDM3A

Across TCGA cell cohorts, KDM3A mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KDM3A-associated genes across cancer lineages are TEX48, PRLHR, and MTNR1B. Each is linked with KDM3A in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM3A-to-partner and partner-to-KDM3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX48 grouped by KDM3A-low versus KDM3A-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM3A→partner) and Y-score (partner→KDM3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TEX48 →	+0.133	+5.000	<.001	.005	3	2
KIDNEY	PRLHR →	+0.030	+5.000	<.001	.005	3	1
KIDNEY	MTNR1B →	+0.103	+5.000	<.001	.005	3	1
KIDNEY	WFDC12 →	+0.066	+5.000	<.001	.005	3	1
KIDNEY	CELA3B →	+0.046	+5.000	<.001	.005	3	1
KIDNEY	AKAIN1 →	+0.090	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

TEX48 by KDM3A expression — KIDNEY

Explore this box plot interactively →