KDM2A

Across TCGA patient cohorts, KDM2A mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM2A-associated genes across cancer lineages are Notch1, eEF2, and MSH2. Each is linked with KDM2A in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM2A-to-partner and partner-to-KDM2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by KDM2A-low versus KDM2A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM2A→partner) and Y-score (partner→KDM2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Notch1 →	+0.186	+2.178	.032	.035	3	2
UCEC	eEF2 →	+0.266	+2.502	.007	.001	3	2
UCEC	MSH2 →	-0.202	-1.821	.001	.007	3	2
UCEC	PDCD4 →	-0.561	-2.736	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.349	-1.523	<.001	.005	3	2
UCEC	ASNS →	+0.255	+1.000	.011	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Notch1 by KDM2A expression — COAD

Explore this box plot interactively →