KDM2A

Across TCGA pan-cancer cohorts, KDM2A RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated KDM2A data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher KDM2A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KDM2A expression acts as an unfavorable survival marker, although some lineages such as SCLC and KIRC show a favorable association.

KICH, ACC, and SCLC are the cancer types where KDM2A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	III,IV	0.208	0.951	<.001	98	view →
ACC	DFS	Median	All	0.256	0.636	<.001	77	view →
SCLC	DFS	Tertile	II,III,IV	0.670	0.377	.008	48	view →
LGG	OS	Median	All	0.375	0.525	<.001	36	view →
PAAD	OS	Median	All	0.412	0.651	.004	36	view →
KIRC	DFS	Median	All	0.751	0.502	<.001	28	view →
LUSC	DFS	Quartile	III,IV	0.206	0.935	.001	25	view →
OV	OS	Median	All	0.261	0.371	<.001	24	view →
MESO	DFS	Tertile	III,IV	0.271	0.514	.010	18	view →
UCS	DFS	Tertile	IV	0.978	0.298	.024	16	view →
UVM	DFS	Median	II,III,IV	0.351	0.575	.016	16	view →
LIHC	DFS	Median	All	0.491	0.591	.016	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

KDM2A–KICH (DFS)

Open the KICH breakdown →