KDM2A

Across TCGA pan-cancer cohorts, KDM2A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of KDM2A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KDM2A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KDM2A is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where KDM2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KDM2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.800	<.001	10	view →
KIRC	Female	All	+0.518	<.001	10	view →
LIHC	Female	II,III,IV	+0.960	<.001	9	view →
STAD	All	II,III,IV	+0.945	<.001	9	view →
LUSC	All	All	+0.394	<.001	6	view →
COAD	Male	II,III,IV	+0.331	.036	4	view →
BRCA	All	II,III,IV	+0.301	<.001	4	view →
LUAD	All	All	+0.282	.004	4	view →
CHOL	Male	All	+2.025	<.001	3	view →
BLCA	Male	III,IV	+0.484	.006	3	view →
THCA	All	All	−0.251	.006	2	view →
COAD	Female	IV	−0.459	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

KDM2A–HNSC

Open the HNSC breakdown →