KDM2A

Across TCGA cell cohorts, KDM2A mutation is significantly associated with the RNA expression of many other genes, with 610 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KDM2A-associated genes across cancer lineages are C4orf50, MORN5, and UBE3A. Each is linked with KDM2A in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM2A-to-partner and partner-to-KDM2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C4orf50 grouped by KDM2A-low versus KDM2A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM2A→partner) and Y-score (partner→KDM2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C4orf50 →	+0.195	+2.974	<.001	.008	3	2
BLOOD_Leukemia	MORN5 →	+0.222	+3.177	<.001	.004	3	2
LARGE_INTESTINE	UBE3A →	+0.684	+3.364	<.001	.002	3	2
LARGE_INTESTINE	TCTE1 →	+0.139	+2.847	<.001	.002	3	2
URINARY_TRACT	HTN1 →	+0.197	+5.044	<.001	<.001	3	1
URINARY_TRACT	SCYGR4 →	+0.026	+4.217	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 610 associations by consensus.

C4orf50 by KDM2A expression — BLOOD_Leukemia

Explore this box plot interactively →