KDM1A

Across TCGA patient cohorts, KDM1A mutation is significantly associated with the RNA expression of many other genes, with 2,598 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM1A-associated genes across cancer lineages are TUBB4BP8, TANGO2, and GTF3C6P3. Each is linked with KDM1A in more than 2 cancer types. Because this analysis shows association rather than direction, both KDM1A-to-partner and partner-to-KDM1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBB4BP8 grouped by KDM1A-low versus KDM1A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM1A→partner) and Y-score (partner→KDM1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TUBB4BP8 →	+0.028	+4.624	<.001	<.001	3	3
UCEC	TANGO2 →	+0.366	+1.662	<.001	.004	3	3
UCEC	GTF3C6P3 →	+0.131	+1.795	.009	<.001	3	2
READ	C22orf42 →	+0.255	+4.097	<.001	.002	3	2
READ	TRAJ1 →	+1.109	+3.931	<.001	.003	3	2
READ	HIKESHIP1 →	+0.545	+4.103	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,598 associations by consensus.

TUBB4BP8 by KDM1A expression — SKCM

Explore this box plot interactively →