KDM1A

Across TCGA pan-cancer cohorts, KDM1A RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of KDM1A’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where KDM1A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KDM1A is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

BLCA, HNSC, and COAD are the cancer types where KDM1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KDM1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	+1.702	<.001	12	view →
HNSC	Male	All	+1.095	<.001	12	view →
COAD	Female	II,III,IV	+1.199	<.001	10	view →
LUAD	Male	All	+0.850	<.001	9	view →
LUSC	Female	All	+1.415	<.001	8	view →
LIHC	Female	II,III,IV	+0.980	<.001	8	view →
STAD	Male	II,III,IV	+1.187	<.001	6	view →
UCEC	All	All	+0.614	.002	6	view →
BRCA	All	II,III,IV	+0.393	<.001	6	view →
KIRC	Male	II,III,IV	−0.391	<.001	6	view →
KICH	Female	All	−0.856	<.001	5	view →
CHOL	Male	All	+1.911	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

KDM1A–BLCA

Open the BLCA breakdown →