KDF1

Across TCGA patient cohorts, KDF1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDF1-associated genes across cancer lineages are GSK-3a-b_pS21_S9, P-Cadherin, and Myosin-IIa_pS1943. Each is linked with KDF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KDF1-to-partner and partner-to-KDF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by KDF1-low versus KDF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDF1→partner) and Y-score (partner→KDF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.477	+3.321	.033	.010	3	1
UCEC	P-Cadherin →	-0.160	-2.990	.034	.036	3	1
UCEC	Myosin-IIa_pS1943 →	+0.275	+2.183	.010	.035	2	1
UCEC	S6_pS240_S244 →	+0.674	+3.321	.001	.010	2	1
UCEC	BRCA2 →	-0.206	-3.162	.003	.019	2	1
UCEC	PRAS40_pT246 →	+0.213	+2.183	.018	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

GSK-3a-b_pS21_S9 by KDF1 expression — UCEC

Explore this box plot interactively →