KDF1

Across TCGA pan-cancer cohorts, KDF1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of KDF1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KDF1 RNA is repressed in tumor relative to normal tissue. In most cancer types KDF1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, BLCA, and KIRP are the cancer types where KDF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KDF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	−2.472	<.001	12	view →
BLCA	All	All	+2.111	<.001	11	view →
KIRP	All	III,IV	−1.548	<.001	11	view →
LUAD	Male	All	+0.745	<.001	9	view →
HNSC	All	All	+0.643	<.001	9	view →
LUSC	All	III,IV	+1.361	<.001	8	view →
KICH	All	All	−0.961	<.001	7	view →
UCEC	All	All	+2.602	<.001	6	view →
BRCA	All	II,III,IV	+1.013	<.001	6	view →
STAD	All	All	+1.465	<.001	5	view →
CHOL	Male	All	+2.235	<.001	4	view →
THCA	Male	IV	−0.370	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

KDF1–KIRC

Open the KIRC breakdown →