KCTD21-AS1

Across TCGA pan-cancer cohorts, KCTD21-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated KCTD21-AS1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher KCTD21-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KCTD21-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and LUAD show a favorable association.

UCS, LUAD, and READ are the cancer types where KCTD21-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	II,III,IV	0.578	0.142	<.001	112	view →
LUAD	OS	Median	All	0.833	0.735	.011	59	view →
READ	DFS	Tertile	All	0.843	0.567	<.001	43	view →
ACC	DFS	Median	All	0.432	0.728	<.001	33	view →
SKCM	DFS	Median	IV	0.187	0.763	.006	22	view →
STAD	OS	Median	II,III,IV	0.458	0.642	.006	16	view →
BRCA	OS	Median	All	0.942	0.906	.010	14	view →
OV	OS	Tertile	IV	0.707	0.453	.010	12	view →
KIRC	DFS	Tertile	IV	0.510	0.739	.016	10	view →
THYM	OS	Quartile	All	1.000	0.725	.011	8	view →
ESCA	DFS	Median	II,III,IV	1.000	0.399	.013	8	view →
BLCA	OS	Median	IV	0.414	0.707	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

KCTD21-AS1–UCS (DFS)

Open the UCS breakdown →