KCTD21-AS1

Across TCGA pan-cancer cohorts, KCTD21-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of KCTD21-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where KCTD21-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KCTD21-AS1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

BLCA, HNSC, and KICH are the cancer types where KCTD21-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCTD21-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+0.889	<.001	9	view →
HNSC	All	All	+0.359	<.001	8	view →
KICH	Female	All	−0.743	<.001	7	view →
UCEC	All	III,IV	+0.553	.016	6	view →
THCA	All	All	−0.398	<.001	6	view →
LIHC	Male	All	+0.531	<.001	5	view →
LUSC	All	All	+0.513	<.001	5	view →
LUAD	All	All	+0.394	<.001	5	view →
ESCA	All	II,III,IV	+0.250	.034	3	view →
COAD	All	All	+0.172	.009	3	view →
STAD	All	II,III,IV	+0.270	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

KCTD21-AS1–BLCA

Open the BLCA breakdown →