Q-omics provides the consensus-scored KCTD21-AS1 profile across patient tissues and cancer cell-line models. KCTD21-AS1 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UCS. Among the 18 cancer types available for tumor–normal comparison, KCTD21-AS1 is differentially expressed in 11, with the highest sampling consensus in BLCA. Additionally, KCTD21-AS1 RNA expression shows 16,804 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UCS, BLCA, and UVM as cancer lineages where KCTD21-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KCTD21-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KCTD21-AS1 survival associations across molecular data types. KCTD21-AS1 RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KCTD21-AS1 RNA expression–survival associations across cancer types. High KCTD21-AS1 expression shows unfavorable associations in ACC, SKCM and STAD, but favorable associations in UCS, LUAD and READ. The UCS Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify UCS as the clearest survival context for KCTD21-AS1 RNA expression.
This table summarizes KCTD21-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in BLCA for RNA.
This table ranks reproducible tumor–normal expression differences for KCTD21-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KCTD21-AS1 shows lower tumor expression in KICH and THCA and higher tumor expression in BLCA, HNSC, UCEC and LIHC. The BLCA box plot shows higher KCTD21-AS1 RNA expression in tumor versus normal tissue (log2 FC = +0.889, t-test p < 0.001).
This table shows molecular features associated with KCTD21-AS1 in patient tissues and cancer cell lines. In patient samples, KCTD21-AS1 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
