KCTD18

Across TCGA patient cohorts, KCTD18 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCTD18-associated genes across cancer lineages are Notch1, TFRC, and EGFR_pY1068. Each is linked with KCTD18 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCTD18-to-partner and partner-to-KCTD18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by KCTD18-low versus KCTD18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD18→partner) and Y-score (partner→KCTD18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.178	+1.887	<.001	.029	3	2
UCEC	TFRC →	+0.429	+1.678	.035	.023	3	2
UCEC	EGFR_pY1068 →	-0.256	-1.678	.007	.023	3	1
UCEC	eIF4E →	+0.171	+2.335	.035	.018	3	1
UCEC	FASN →	+0.333	+1.678	.027	.023	3	1
UCEC	FoxM1 →	+0.280	+2.087	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Notch1 by KCTD18 expression — UCEC

Explore this box plot interactively →