KCTD18

Across TCGA pan-cancer cohorts, KCTD18 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated KCTD18 data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher KCTD18 RNA is associated with better overall survival. In most high-consensus cancer types, elevated KCTD18 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

KIRC, SKCM, and UCS are the cancer types where KCTD18 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.702	0.559	<.001	110	view →
SKCM	OS	Quartile	II,III,IV	0.365	0.222	<.001	60	view →
UCS	DFS	Tertile	II,III,IV	0.575	0.122	.003	54	view →
KIRP	OS	Median	IV	0.040	0.525	.002	36	view →
BRCA	DFS	Tertile	III,IV	0.897	0.726	.001	29	view →
ACC	DFS	Tertile	All	0.320	0.715	.002	28	view →
MESO	OS	Median	IV	0.810	0.338	.002	28	view →
UVM	DFS	Quartile	III,IV	0.215	0.814	.008	15	view →
SARC	DFS	Median	All	0.588	0.436	.003	11	view →
PRAD	DFS	Quartile	All	0.941	0.861	.021	10	view →
KICH	DFS	Quartile	III,IV	0.242	1.000	.010	9	view →
THYM	DFS	Quartile	All	1.000	0.861	.019	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

KCTD18–KIRC (OS)

Open the KIRC breakdown →