KCTD18

Across TCGA pan-cancer cohorts, KCTD18 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KCTD18’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KCTD18 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KCTD18 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, KICH, and THCA are the cancer types where KCTD18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCTD18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.437	<.001	10	view →
KICH	Female	II,III,IV	−1.105	<.001	9	view →
THCA	Male	All	−0.662	<.001	9	view →
UCEC	All	All	−0.723	<.001	6	view →
LIHC	Male	All	+0.620	<.001	6	view →
CHOL	All	All	+1.451	<.001	5	view →
BRCA	Female	All	−0.201	<.001	4	view →
COAD	All	All	−0.195	.043	3	view →
BLCA	Male	IV	−0.714	.009	2	view →
HNSC	All	III,IV	+0.359	.042	1	view →
READ	All	All	−0.348	.044	1	view →
LUAD	All	III,IV	−0.274	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KCTD18–KIRC

Open the KIRC breakdown →