KCTD18

Across TCGA cell cohorts, KCTD18 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCTD18-associated genes across cancer lineages are IL3, KRTAP2-4, and OOSP4A. Each is linked with KCTD18 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCTD18-to-partner and partner-to-KCTD18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL3 grouped by KCTD18-low versus KCTD18-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD18→partner) and Y-score (partner→KCTD18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IL3 →	+0.072	+5.369	<.001	.004	3	1
SOFT_TISSUE	KRTAP2-4 →	+0.147	+4.930	<.001	.008	3	1
SOFT_TISSUE	OOSP4A →	+0.067	+4.930	<.001	.008	3	1
OVARY	GZMH →	+0.060	+5.807	<.001	.001	3	1
OVARY	SLC22A24 →	+0.013	+5.196	<.001	.005	3	1
BLOOD_Lymphoma	DPPA4 →	+0.608	+4.350	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

IL3 by KCTD18 expression — SOFT_TISSUE

Explore this box plot interactively →