KCNQ4

Across TCGA patient cohorts, KCNQ4 mutation is significantly associated with the RNA expression of many other genes, with 1,491 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNQ4-associated genes across cancer lineages are AP1S3, LZIC, and SAP30. Each is linked with KCNQ4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNQ4-to-partner and partner-to-KCNQ4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AP1S3 grouped by KCNQ4-low versus KCNQ4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ4→partner) and Y-score (partner→KCNQ4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AP1S3 →	+0.643	+1.716	<.001	.006	3	2
UCEC	LZIC →	+0.501	+2.128	.002	.002	3	2
UCEC	SAP30 →	+0.515	+2.606	.003	.005	3	2
UCEC	SFXN1 →	+0.463	+2.160	<.001	.002	3	2
UCEC	ZNF367 →	+0.765	+3.480	<.001	.002	3	2
UCEC	LEO1 →	+0.447	+3.732	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,491 associations by consensus.

AP1S3 by KCNQ4 expression — UCEC

Explore this box plot interactively →