KCNQ4

Across TCGA patient cohorts, KCNQ4 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. COAD shows the largest number of these associations.

The most reproducible KCNQ4-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and Caspase-8. Each is linked with KCNQ4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNQ4-to-partner and partner-to-KCNQ4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KCNQ4-low versus KCNQ4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ4→partner) and Y-score (partner→KCNQ4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.305	+3.016	<.001	.018	3	2
UCEC	ATM →	-0.517	-3.446	.003	.005	3	2
UCEC	Caspase-8 →	-0.206	-2.459	.036	.019	3	2
COAD	ASNS →	+0.703	+3.178	<.001	.010	3	1
COAD	4E-BP1_pT70 →	+0.126	+3.178	.033	.010	3	1
SKCM	ACVRL1 →	+0.161	+2.820	.032	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Caspase-7-cleavedD198 by KCNQ4 expression — COAD

Explore this box plot interactively →